Your doctor can use rbc indices to help diagnose the cause of anemia. Anemia is defined by a hemoglobin hgb value at least two standard deviations below the mean for age and sex anemia is the most common anemia. The rbc indices measure the size, shape, and physical characteristics of the rbcs. Pubmed is a searchable database of medical literature and lists journal articles that discuss hypochromic microcytic anemia with iron overload. Classification of anemia diagnostic approach to anemia. Microcytic anemia is a condition in which the bodys tissues and organs do not get enough oxygen. If they are absent, the anemia is nonmegaloblastic.
Evaluation of microcytosis american family physician. Figure 1 is a suggested algorithm for diagnosing the cause of. It is found more common in females of all age groups primarily due to. Anemia is associated with increased morbidity and mortality in older adults. Microcytic anemia is characterized by smallerthannormal red cells due to decreased production of hemoglobin.
Deficiency results in megaloblastic anemia due to impaired. A nemia is defined as reduction in number of red blood cells or hemoglobin, resulting in lower oxygen carrying capacity. Hypochromic microcytic anemia with iron overload genetic. The causes are numerous, and the evaluation depends on a synthes. Microcytic anemia may result from several different etiologies, including iron deficiency anemia, thalassemia, or anemia of chronic diseaseinflammation. The diagnosis of anemia depends on lab investigations and a brief approach to anemia. Many cases can be treated with supplements and diet changes to increase your iron intake. Is the anemia microcytic small red blood cell size. Deficiencies of multiple nutrients eg, malabsorption or the use of thiopurine medications eg, azathioprine in ibd can lead to a combination of iron deficiency anemia and macrocytosis, with resultant normocytic anemia. Microcytic anemia refers to any anemia in which the mean corpuscular volume mcv of red blood cells rbcs is low.
If these cells are present, the anemia is megaloblastic. Figure caption and citation for the preceding image starts. Pdf etiological study of microcytic hypochromic anemia. Etiological study of microcytic hypochromic anemia. Microcytic hypochromic anaemia in contrast to normal blood smear 3 figure 1. Who definition for anemia is hemoglobin less than gmdl for men and less than 12gmdl for women. Diagnostic approach to anemia arup laboratories university of. Microcytic anemia ma and hypochromic anemia ha is one of the pathological condition concerned with all age group. The most common causes of microcytosis are iron deficiency anemia and thalassemia trait.
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